Lupus is a long-term autoimmune disease in which the body's immune system becomes hyperactive and attacks normal, healthy tissue. Symptoms vary but can include fatigue, joint pain, rash, and fever. These can periodically get worse (flare-up) and then improve. While there's no cure for lupus, current treatments focus on improving quality of life through controlling symptoms and minimizing flare-ups. Get ready to learn more about Lupus?